Results 551-560 of about 1,000
- The immune response is a primary hurdle in the development of gene therapy for neuromuscular diseases. Both innate and adaptive immune responses have been observed in human trials. The canine model is an excellent platform to understand immunological
Date: (2023) Authors: Chady H. Hakim , Sandeep R. Kumar , Dennis Pérez-López , James Teixeira ... Dongsheng Duan Ref: Muscular Dystrophy Therapeutics Date: 2024-01-01 Authors: Kola NS, Patel D, Thakur A. Journal: Methods in molecular biology (Clifton, N.J.) - CRISPR-based base editors are efficient genome editing tools for use in base correction. Currently, there are various versions and types of base editors with different substitution patterns, editing windows, and protospacer adjacent motif (PAM)
Date: (2023) Authors: Gue-Ho Hwang , Sangsu Bae Ref: Base Editors - Genetically engineered myeloid cells such as monocytes, macrophages, and dendritic cells have broad applications in basic and translational research. Their central roles in innate and adaptive immunity make them attractive as putative therapeutic
Date: (2023) Authors: Emily C. Freund , Simone M. Haag , Benjamin Haley , Aditya Murthy Ref: Dendritic Cells - VEuPathDB Resources: A Platform for Free Online Data Exploration, Integration, and Analysis. new window
Date: 2024-01-01 Authors: Harb OS, McDowell MA, Roos DS. Journal: Methods in molecular biology (Clifton, N.J.) - Sequence-specific gene regulation by small RNA (sRNA) pathways is essential for the development and function of organisms in all domains of life. These regulatory complexes, containing an Argonaute protein (AGO) guided by a bound sRNA, have the
Date: (2023) Authors: Mathias S. Renaud , Uri Seroussi , Julie M. Claycomb Ref: Germline Stem Cells - A genetic disorder is a disease caused by an abnormal DNA sequence, and almost half of the known pathogenic monogenetic mutations are caused by G-to-A mutation (Landrum et al., Nucleic Acids Res 44:D862–868, 2016). Adenine base editors (ABE),
Date: (2023) Authors: Dong Yang , Chun-Qing Song Ref: Base Editors Date: 2024-01-01 Authors: Soto-Angel JJ, Nordmann EL, Sturm D, Sachkova M, Pang K, Burkhardt P. Journal: Methods in molecular biology (Clifton, N.J.) - In image-based profiling, software extracts thousands of morphological features of cells from multi-channel fluorescence microscopy images, yielding single-cell profiles that can be used for basic research and drug discovery. Powerful applications
Date: (2023) Authors: Beth A. Cimini , Srinivas Niranj Chandrasekaran , Maria Kost-Alimova , Lisa Miller ... Anne E. Carpenter - Medaka (Oryzias latipes), along with zebrafish (Danio rerio), is a useful experimental model fish. Here, we describe a simple method for generating medaka gene knockout strains using an automated microchip electrophoresis system. We also describe a
Date: (2023) Authors: Rie Hara , Satoshi Ansai , Masato Kinoshita Ref: Genome Editing in Animals