Results 271-280 of about 359
Date: (2020) - An improved sequential fluorescence in situ hybridization approach allows one to image the expression of 10,000 genes in single cells.
Date: (2019) Authors: Alfredo Sansone - Embryonic development is heavily dependent on temporally and spatially restricted gene expression. Spatially resolved measurements of gene expression are therefore crucial for identifying novel regulators and the understanding of their function.
Date: (2019) Authors: Karoline Holler , Jan Philipp Junker Ref: Vertebrate Embryogenesis - A Hidden Markov Random Field Model for Detecting Domain Organizations from Spatial Transcriptomic Data new windowCells in complex tissues are organized by distinct microenvironments and anatomical structures. This spatial environment of cells is thought to be important for division of labor and other specialized functions of tissues. Recently developed spatial
Date: (2019) Authors: Qian Zhu Ref: Computational Methods for Single-Cell Data Analysis - The emerging diversity of single-cell RNA-seq datasets allows for the full transcriptional characterization of cell types across a wide variety of biological and clinical conditions. However, it is challenging to analyze them together, particularly
Date: (2019) Authors: Ilya Korsunsky , Nghia Millard , Jean Fan , Kamil Slowikowski ... Soumya Raychaudhuri - Medium-Throughput RNA In Situ Hybridization of Serial Sections from Paraffin-Embedded Tissue Microarrays new window(m)RNA spatiotemporal pattern of distribution is of key importance to decipher gene function. In this post-genomic era, numerous transcriptomic studies are made publicly available, sometimes reaching a tissular resolution and even more rarely the
Date: (2019) Authors: Edith Francoz , Philippe Ranocha , Christophe Dunand , Vincent Burlat Ref: Plant Long Non-Coding RNAs - The recent technological developments in the field of single-cell RNA-Seq enable us to assay the transcriptome of up to a million single cells in parallel. However, the analyses of such big datasets present a major challenge. During the last decade,
Date: (2019) Authors: Kevin Baßler , Patrick Günther , Jonas Schulte-Schrepping , Matthias Becker , Paweł Biernat Ref: Single Cell Methods - Multiplexed tissue imaging enables precise, spatially resolved enumeration and characterization of cell types and states in human resection specimens. A growing number of methods applicable to formalin-fixed, paraffin-embedded (FFPE) tissue sections
Date: (2019) Authors: Ziming Du , Jia-Ren Lin , Rumana Rashid , Zoltan Maliga ... Sandro Santagata - Sample multiplexing facilitates scRNA-seq by reducing costs and identifying artifacts such as cell doublets. However, universal and scalable sample barcoding strategies have not been described. We therefore developed MULTI-seq: multiplexing using
Date: (2019) Authors: Christopher S. McGinnis , David M. Patterson , Juliane Winkler , Daniel N. Conrad ... Zev J. Gartner - Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa new windowRetinitis pigmentosa (RP) is a complex inherited disease. It is associated with mutations in a wide variety of genes with many different functions. These mutations impact the integrity of rod photoreceptors and ultimately result in the progressive
Date: (2019) Authors: Malte Lehmann , Elisabeth Knust , Sarita Hebbar Ref: Retinal Degeneration