Results 301-310 of about 900
- Macrophages are an abundant population in the tumor-infiltrating immune cells. The transcription factor NF-κB plays an important role in the response of tumor-associated macrophages (TAMs) to the tumor environmental cues. Detecting NF-κB activity in
Date: (2021) Authors: Fan Sun , Zhaoxia Qu , Gutian Xiao Ref: NF-κB Transcription Factors - Quantifying RNA synthesis at rate-limiting steps of transcription using nascent RNA-sequencing data. new window
Date: 2022-01-05 Authors: Rabenius A, Chandrakumaran S, Sistonen L, Vihervaara A. Journal: STAR protocols - Deciphering the Dynamic Landscape of Transcription-Associated mRNP Quality Control Components Over the Whole Yeast Genome new windowIn eukaryotic cells, aberrant mRNPs with processing and packaging defects are targeted co-transcriptionally by a surveillance system that triggers their nuclear retention and ultimately the degradation of their mRNA component by the 3′–5′ activity of
Date: (2021) Authors: Kévin Moreau , Aurélia Dantec , A. Rachid Rahmouni Ref: RNA Remodeling Proteins - The nucleosome is the basic organizational unit of the genome. The folding structure of nucleosomes is closely related to genome functions, and has been reported to be in dynamic interplay with binding of various nuclear proteins to genomic loci.
Date: (2021) Authors: Masae Ohno , Tadashi Ando , David G. Priest , Yuichi Taniguchi Date: 2022-01-01 Authors: Finn E, Misteli T, Pegoraro G. Journal: Methods in molecular biology (Clifton, N.J.) - The MYC oncogene was originally identified as a transduced allele (v-myc) in the genome of the highly oncogenic avian retrovirus MC29. The protein product (MYC) of the cellular MYC (c-myc) protooncogene represents the key component of a transcription
Date: (2021) Authors: Markus Hartl , Klaus Bister Ref: The Myc Gene - Epigenetic editing is an emerging technology that uses artificial transcription factors (aTFs) to regulate expression of a target gene. Although human genes can be robustly upregulated by targeting aTFs to promoters, the activation induced by
Date: (2021) Authors: Y. Esther Tak , Joy E. Horng , Nicholas T. Perry , Hayley T. Schultz ... J. Keith Joung Date: 2022-01-01 Authors: de Nicola F, Corleone G, Goeman F. Journal: Methods in molecular biology (Clifton, N.J.) - Illuminating Enhancer Transcription at Nucleotide Resolution with Native Elongating Transcript Sequencing (NET-Seq) new windowEnhancers are transcribed by RNA polymerase II (Pol II). In order to study the regulation of enhancer transcription and its function in target gene control, methods are required that track genome transcription with high precision in vivo. Here, we
Date: (2021) Authors: Olga Jasnovidova , Mirjam Arnold , Andreas Mayer Ref: Enhancers and Promoters - Identifying and Validating MYC:Protein Interactors in Pursuit of Novel Anti-MYC Therapies new windowBy identifying MYC protein–protein interactors, we aim to gain a deeper mechanistic understanding of MYC as a regulator of gene transcription and potent oncoprotein. This information can then be used to devise strategies for disrupting critical MYC
Date: (2021) Authors: Diana Resetca , Alannah S. MacDonald , Tristan M. Kenney , Yong Wei ... Linda Z. Penn Ref: The Myc Gene